I went from apple everything to Android phone and tablet, (kept the macbook thought) I found it pretty straight forward, and just kept finding extra features as time passed. It was the same when I went from Vaio to Macbook. The simplicity and the straightforward functionality was great once I got used to it. Apple is designed to be for everyone albeit not priced as such and Android is too to some extent but the limitations with apple for me now I just can't go back. I keep wanting to quit the app drawer being the most irritating feeling, I found when using the both side by side recently.
As for syncing, yes it is possible to do it. However you do lose iTunes and movies if you have any media or paid for apps all those will be lost until you return to apple. In my case Tweetbot has released a whole new app update it seems and mine is hidden away under purchases.